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亚博游戏:李 力 教授

时间:2020-04-13浏览:14115

 


  

  李力

  亚博游戏,亚博游戏,教授,博士生导师

 




 

教育经历:

2004/4-2008/12,上海交通大学,生命科学与技术学院,博士

1998/9-2001/7,福建农林大学,植物保护系,硕士

1994/9-1998/7,厦门大学,生物系,本科


科研工作经历:

1. 2008/12-至今亚博游戏,亚博游戏,讲师、副教授和教授

2. 2015/32017/2 加州大学洛杉矶分校,化学与生物工程系,访问学者

3. 2010/10-2011/10 加州大学洛杉矶分校,化学与生物工程系,博士后


社会兼职:

中国微生物学会分子微生物学及生物工程专业委员会委员;中国菌物学会药用真菌专业委员会委员;农工民主党福建省青年工作委员会委员。


主要研究方向:

1. 微生物天然产物的发现与基因组挖掘:我们利用真菌或放线菌基因组的信息,通过基因激活技术和异源表达手段,挖掘出新颖天然产物;

2. 工业微生物的基因工程与代谢工程:我们的研究包括菌种的选育、基因工程和代谢工程的改造以实现从实验室到生产的衔接,产品包括酶和代谢产物。


招生方向(欢迎各位同学报考):

博士研究生:微生物学专业;硕士研究生:微生物学专业、生物化学与分子生物学专业、生物工程专业、生物技术与工程(专业学位)


在研项目:

1)国家重点研发计划合成生物学专项课题,2021YFA0910501,先导化合物生物合成路径的解析及骨架相关元件库的构建,2021/12-2026/11 (负责人)

2)国家自然科学基金面上项目,32170069,一种靶向AHAS的真菌天然除草化合物的发现及作用机制,2022/01- 2025/12 (负责人)

3)国家自然科学基金面上项目,31870039,进化树指导下真菌新颖聚酮-非核糖体肽化合物发现与生物合成研究,2019/01-2022/12 (负责人)

4)福建省自然科学基金面上项目,2021J01173,红曲菌天然活性物质的挖掘及无毒生产菌株的构建,2021/11-2024/11 (负责人)

5)福建省第五轮卫生教育联合攻关计划项目,基于代谢组学分析肠道微生物对过敏性鼻炎发生的影响,2019/12-2022/12(负责人)


主要研究论文:

1.  Gao, Y, Yu C, Li L*. Heterologous expression of a natural product biosynthetic gene cluster from Cordyceps militaris. Journal of Antibiotics 2022. 75(1): 16-20  

2.  Gao, Y#, Xie M#, Yu C, Zhang M, Huang J, Li Q, Zhang H, Li L*. Heterologous Expression of Macrollins from Phytopathogenic Macrophomina phaseolina Revealed a Cytochrome P450 Mono-oxygenase in the Biosynthesis of β-Hydroxyl Tetramic Acid. Journal of Agricultural and Food Chemistry 2021, 69(50): 15175-15183

3.  Zhang M, Zhang H*, Li Q, Gao Y, Guo L, He L, ZangS, Guo X, Huang J*, Li L*. Structural Insights into the Trans-Acting Enoyl Reductase in the Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Shewanella piezotolerans. Journal of Agricultural and Food Chemistry 2021, 69(7): 2316-2324.

4.  Gao Y-L, Zhang M-L, Wang X, Zhang H-D, Huang J-Z, Li L*. Isolation and characterization of a new cytotoxic polyketide–amino acid hybrid from Thermothelomyces thermophilus ATCC 42464. Natural Product Research 2021,35(11): 1792-1798.

5.  Wang X, Gao Y-L, Zhang M-L, Zhang H-D, Huang J-Z, Li L*. Genome mining and biosynthesis of the Acyl-CoA:cholesterol acyltransferase inhibitor beauveriolide I and III in Cordyceps militaris. Journal of Biotechnology 2020, 309: 85-91.

6.    Zhang Y, Zhang Y, Li M, Li L*, Tang X*, Gao J*. Homogenization significantly enhances growth of macroalga Saccharina japonica female gametophytes. Algal Research 2019, 43: 101640. 

7.    Li L#, Tang M-C#, Tang S, Gao S, Soliman S, Hang L, Xu W, Ye T, Watanabe K, Tang Y. Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids. Journal of the American Chemical Society 2018, 140(6): 2067-2071.

8.    Li L, Huang J, Lin Y. Snake Venoms in Cancer Therapy: Past, Present and Future. Toxins 2018, 10(9).

9.    Zou Y, Garcia-Borràs M, Tang MC, Hirayama Y, Li DH, Li L, Watanabe K, Houk KN, Tang Y. Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. Nature Chemical Biology 2017, 13(3): 325-332.

10.   Li L, Yu P, Tang M-C, Zou Y, Gao S-S, Hung Y-S, Zhao M, Watanabe K, Houk KN, Tang Y. Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase. Journal of the American Chemical Society 2016, 138(49): 15837-15840.

11.   Bond C#, Tang Y, Li L#. Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases. Fungal Genetics and Biology 2016, 89: 52-61.

12.   Yu G, Li L, Liu X, Liu G, Deng Z, Zabriskie MT, Jiang M, He X. The standalone aminopeptidase PepN catalyzes the maturation of blasticidin S from leucylblasticidin S. Scientific Reports 2015, 5(1): 17641.

13.   Han T, Yamada-Mabuchi M, Zhao G, Li L, liu G, Ou H-Y, Deng Z, Zheng Y, He X. Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins. Nucleic Acids Research 2015, 43(2): 1147-1159.

14.   Li L, Wang P, Tang Y. C-glycosylation of anhydrotetracycline scaffold with SsfS6 from the SF2575 biosynthetic pathway. Journal of Antibiotics 2014, 67(1): 65-70.

15.   Li L#, Wu J#, Deng Z, Zabriskie TM, He X. Streptomyces lividans Blasticidin S Deaminase and Its Application in Engineering a Blasticidin S-Producing Strain for Ease of Genetic Manipulation. Applied and Environmental Microbiology 2013, 79(7): 2349.

16.   Wu J#, Li L#, Deng Z, Zabriskie TM, He X. Analysis of the Mildiomycin Biosynthesis Gene Cluster in Streptoverticillum remofaciens ZJU5119 and Characterization of MilC, a Hydroxymethyl cytosyl-glucuronic Acid Synthase. ChemBioChem 2012, 13(11): 1613-1621.

17.   Liu G, Ou H-Y, Wang T, Li L, Tan H, Zhou X, Rajakumar K, Deng Z, He X. Cleavage of Phosphorothioated DNA and Methylated DNA by the Type IV Restriction Endonuclease ScoMcrA. PLOS Genetics 2010, 6(12): e1001253.

18.   Li L, Xu Z, Xu X, Wu J, Zhang Y, He X, ZabriskieTM, Deng Z. The Mildiomycin Biosynthesis: Initial Steps for Sequential Generation of 5-Hydroxymethylcytidine 5′-Monophosphate and 5-Hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119. ChemBioChem 2008, 9(8): 1286-1294.

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



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